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I have a Mac Mini (mid 2010 model) with 8GB of RAM, running OSX 10.9.2 and the latest iTunes 11.1.5. I send audio out to a Wyred4Sound DAC-2 via USB; it then goes through my amp and into my headphones. I also use either BitPerfect or Audirvana Plus (in iTunes integrated mode). No problems at all, until installing Mavericks (1o.9.1 and 10.9.2) and the newest versions of iTunes. (probably the last two updates). What I'm hearing is right at the beginning of each new track as it starts to play. There are crackling, popping noises; not loud, but certainly audible. It sounds a bit like dropping the needle between tracks on a noisy vinyl record. Sometimes, the first couple of seconds of the tracks will stutter and repeat, as well. Once the track gets going, it's usually fine. Occasionally, I'll hear a glitch somewhere in the middle of the track as well. I've been through the manuals for both BitPerfect and Audirvana, and tried all of the different pref settings that are suggested to stop this sort of thing (i.e. stopping gapless playback,integer mode on/off, iTunes interaction, etc.) No combination of settings that I've found will eliminate these crackling noises completely. BitPerfect support has been excellent; they've even sent me an experimental version to try, which seemed to help somewhat, but the noises still appear now and then. The only way I can eliminate the glitches completely is to run iTunes directly without using either BitPerfect or Audirvana Plus. I don't hear a huge difference in audio quality with either program, but I enjoy the automatic sample rate switching. To get around that, I've just set my W4S DAC-2 to upsample everything to 192kHz, since iTunes alone can't do it. I would love to get either or both of these players back in the chain again, but right now the only noise-free listening I can get is when I am bypassing them. I know that a lot of people had many diverse audio problems with iTunes and other software when Mavericks first came out, but most people reported them solved with 10.9.2, or with the newest iTunes. If anyone has any suggestions, I'd really appreciate it. Thanks in advance.