Jump to content

bluesman

  • Content Count

    1623
  • Joined

  • Last visited

About bluesman

  • Rank
    Crusty Old Curmudgeon

Recent Profile Visitors

6260 profile views
  1. This is called "boron neutron capture therapy" (BNCT), and much of the research on it focuses on recurrent head & neck cancer. I'm a facial plastic & reconstructive surgeon in an NCI designated cancer center (retired after about 40 years of academic practice but still in active research as a tenured professor). So I have a tiny bit of familiarity with and understanding of some of the healthcare tangents introduced in this thread. The data based answer is: It hasn't proven sufficiently effective in clinical trials to justify routine clinical use. It's being modified with additional treatment modalities like pulsed ultrasound and epithermal neutron beam irradiation in attempts to improve cure & control rates without the severe toxicity seen to date. There are some isolated reports of complete responses of varied duration, but outcomes to date do not justify adoption because it hasn't yet improved care. The required radiation beam has to be generated by a very specialized, rare, expensive, dedicated nuclear reactor of which there were only a few in the world up to 2014. Since then, US and Japanese sources have made a few accelerator-based neutron sources - but outcomes data to date are simply not positive enough to justify investment beyond those required for research. The biggest problem at present seems to be the difficulty of developing optimal boron delivery agents. This is not for lack of trying, as evidenced by many published studies over the last 40+ years and the fact that there are still only two drugs for clinical use. Creating and improving these agents is a lot harder than it has been to date for chemotherapeutic agents. Boron delivery agents must persist in tumor cells long enough to be useful, while clearing from surrounding normal tissue fast enough to leave an ideal concentration gradient of between 3 and 4 to 1. Problems also include the need for development of methods to provide more accurate estimates of tumor boron content before treatment, improvements in clinical implementation of BNCT, and a clear need for randomized clinical trials with an unequivocal demonstration of therapeutic efficacy. Research is active in glioblastoma, head & neck cancer, and (as I recall) a few genital cancers. But this remains an early stage effort for the above reasons.
  2. bluesman

    I don't know what I want, but I need something

    Hi & welcome, Paul! If I understand you correctly, you run only Linux on your computers. This leaves out Foobar2000, an excellent freeware music management & playing system that's only available for Windows. I've run it on Ubuntu using Wine, which works well - but it's a bit labor intensive in use compared to several simpler options. It'd be easier to start out with any current basic audio player for Linux (e.g. Clementine, Amarok, Banshee, Rhythmbox, etc). You already have your FLACs on a drive, so that drive is obviously accessible to at least one of your computers or you couldn't have gotten the files onto it. Start by playing the files from where they are, using one of the above programs. Drive your new DAC with a USB output from your computer. If you have an RPi 3 or newer sitting around, just download dietpi and burn the image to a microSD card. Stick it into your Pi, boot it up, and follow the instructions on the screen (with help from the dietpi website as needed) to configure it and install a player from their software repository. There are several flavors of freeware player, including a few MPD instances, Kodi, LMS, Plex etc. You can use Volumio, Moode, Daphile etc with equally pleasing results. There's now a Roon server option from Dietpi that I don't recall seeing in the past - so you can take advantage of the Roon free trial to see if you think it's worth the cost (which I do).The Roon downloads page still has no option for a server instance on an ARM board, and (in my experience) the 64 bit Linux server package is a bit processor-heavy for use on a Pi. There are packages for running the Roon server on QNAP and Synology NAS units, but those requirements start with an Intel i3. Roon's comment on running the NAS server packages on anything less powerful is a simple and euphemistic "Overall, the experience will not be as good as it can be". So I assume (for no good reason other than that it makes sense - it's possible that Roon Labs will add this to the downloads page as I type...) that the Dietpi version of Roon server is adopted by them (rather than by Roon) from the available Linux version. I'm downloading it as we speak to figure out what it is and how well it performs. You can run JRiver Media Center from a Pi - I've have a full instance running for a few years as a web server streaming to my son's house, phones and car. The graphics are a bit slower than they are from a more powerful machine, and functionality is limited - but most of the limits are on features you don't use or need for audio use. You can stick the SSD with the FLACs on it into an external housing and use it as a USB drive on whatever device you decide to adopt as your player. But if all of the USB ports on that device are on the same bus, you may compromise performance and SQ using that bus for both file input and digital audio output to your DAC. You'd be better served by either mounting the SSD as a second internal drive in a computer or accessing the SSD via your network (i.e. in a NAS box) if you have to use USB for audio out to your DAC.
  3. bluesman

    Who Can You Trust?

    Yes. I may be doomed to disappointment, but I expect exactly that if it's what the reviewer found and believes. It'd be nice to have some kind of corroborating evidence as well. As the old book says, "man's reach should exceed his grasp".
  4. bluesman

    Article: Roon Vs. JRiver | Clash of the Titans

    You are correct. This moderator post on the Roon Community site explains: “Roon does not add any information to your base files. So any updates, edits, etc made in Roon stay in Roon. This is by design. Many people, myself included, perfect the files metadata before putting it into Roon. Basically, if I download a file or Rip a CD, I do so to a staging area. I then review the metadata, make changes if wanted or necessary, and then move it to the Roon watched folders.” You can add group tags, which would let you delineate boxed sets. You can add comment tags to files that will identify the source. You can even add “hidden” tags that are only searchable and visible for you. The only limitation is your imagination. All such tags are usable in Roon but are not included in file metadata, so they’re invisible to other players like JRMC. It works great for me.
  5. bluesman

    Relative importance of differences in stereo systems

    As 70 fades in my rear view mirror, it's clear that the young 'uns can be mighty funny creatures, Sal. The older they get, the smarter we get. Just stay in the groove, man' - many will eventually catch on and catch up.
  6. bluesman

    Relative importance of differences in stereo systems

    ...because of your reaction to my comment on STC's statement that "...[t]o be an audiophile you need to have high end equipment", specifically : After clinging tightly to my innocence for 7 decades, I had to let it go when confronted with "It was statement to emphazise the importance of room acoustics... Today, audiophile refers to lifestyle and branded equipment despite what they claim to be. Like the Audioquest and Wadia DAC that you are using." I don't know who "they" are, but they seem not to approve of my equipment choices. This interchange opened my eyes! I'm with you - I'm wasting my breath and sticking my neck out for no good reason. It's no longer my concern. I hope that everyone can and does pursue his or her passions, and that each gets as much pleasure and satisfaction from them as you and I and our wives do from ours. But I will not again intervene - let everyone make his or her choices and live with them. In fact, you've inspired me to set up MC! I'd forgotten all about my Pioneer Elite 7.1 receiver, which I put in the closet when we sold the house 3 years ago. The Wolfson 24/192 DACs may not be "audiophile quality" 😉, but they're a start. I'll find out how important differences in the system are to me as I develop this.
  7. bluesman

    Relative importance of differences in stereo systems

    My profound apologies, Kal. As usual, you were 100% correct - it really isn’t my concern. From now on, it’s omnis homo sibi!
  8. bluesman

    Relative importance of differences in stereo systems

    Your passion and equanimity are laudable, Kal - I'm also fortunate enough to possess a fair measure of each. But you seem to have less contact with the many conflicted and unhappy souls out there than I do. And as a physician, it absolutely is my concern if I can be of any help to any of them. While many - OK, maybe most - people see things differently from me, those who get their joys from belittling the tastes and pursuits of others are hurtful, and they abound. Helping an AS newbie to be as positive as you are about his or her passions and efforts to engage them is a wonderful, worthwhile endeavor that demonstrates what it means to you and me to be an audiophile. We are very lucky to be us, my friend!
  9. bluesman

    Relative importance of differences in stereo systems

    First, they came for the bagpipers, and I did not speak out - because I was not a bagpiper. Then they came for the accordionists, and I did not speak out - because I was not an accordionist. Then they came for the misguided, and I did not speak out - because I was not misguided. Then they came for me - and there was no one left to speak for me. [Yes, officer - my poetic license is in my wallet ] Sadly, many friends and people I meet over music, audio, art etc let this kind of thinking push them into doubting their own ears and judgment. They spend far more than they need to (and, in many cases, can afford to) to avoid preachy, condescending and most often unfounded criticism. So, with tongue only partly in cheek, I responded to support them. They're audiophiles in the true sense of the word, they don't need to buy anything to deserve the title, and there are a lot of them. To keep it on topic, I think that the marginal importance of differences in stereo systems approaches zero asymptotically above a cost threshold that's dropping like a rock. Sound quality today is so good from very basic equipment that diminishing returns set in lower than ever before. It's an audiophile's paradise out there now, and I love it!
  10. bluesman

    Relative importance of differences in stereo systems

    I'm more than a bit surprised at the lack of response to this statement. The term "audiophile" is often used pejoratively, e.g. as Ken Rockwell does: "Audiophiles are what's left after almost all of the knowledgeable music and engineering people left the audio scene back in the 1980s." "audiophiles don't have the experience or education to understand what matters" But I think Rockwellians are a bit harsh in seeing pursuit of expensive audio equipment purely or primarily as ignorant and conspicuous consumption, despite their occasional confluence. And if that were the context of the quoted post, I would have expected something like "To be an audiophile, you need to have fancy, costly, exotic, highly rated equipment". Thankfully, it seems more like an innocently elitist term in the posted context - so I only have to take polite issue with it. For me and multiple excellent dictionaries like Webster ("a person who is enthusiastic about high-fidelity sound reproduction") and Cambridge ("a person who is very interested in and enthusiastic about equipment for playing recorded sound, and its quality"), being an audiophile requires only interest and enthusiasm. I can find no hardware requirements. Maybe I'm not a true audiophile. Over the 60+ years I've been whatever it is that I am, I've generally spent 5% or less of the cost of contemporary "high end" systems on my own stuff. Sadly, I had to settle for only about 90+% of the sound quality I could have gotten had I used my money for "better" audio equipment instead of education, guitars, cars, women, clothes, wine, travel, cameras, bicycles, motorcycles, family, house, and............music And every once in a while, the audio gods allow the weaknesses in my system to cancel each other and grace me with an outstanding listening session, for which I am truly thankful (and aware that my approach to audiophilia does not merit such joy). In retirement, I continue to struggle with the sonic & functional limitations imposed by less-than-high-end equipment. Fortunately, I've been able to resist conscious depression, despite suffering from a 50 year old Thorens & SME, i3- and ARM-based computers, entry level Audioquest wires, Emotiva and Wadia DACs, powered JBLs, and Prima Luna amplification driving Focal 726s and Rogers LS3/5a speakers, and similarly limiting stuff. Even my piano is only a Yamaha. Be aware that many others suffer the same pain in silence. But we soldier on, because we're - - AUDIOPHILES!
  11. bluesman

    5G - Are We Safe Or Insane?

    Say watt????
  12. bluesman

    5G - Are We Safe Or Insane?

    You’ll have to sine on the dotted line to catch that wave.
  13. bluesman

    5G - Are We Safe Or Insane?

    And if the 28G spectrum brings $10+ million in Wisconsin, imagine what they'll get for 20-20K in New York!
  14. bluesman

    Jesus Wept

    An F sharp quarter note walks into a bar and orders a beer. He takes a sip and immediately spits it out. The bartender runs over and says "What's wrong with it?" The note replies, "Be flat".
×